(R)-2-Amino-2-(2-propenyl)propionsaeure-methylester

Base Information

• Chemical Name: (R)-2-Amino-2-(2-propenyl)propionsaeure-methylester
• CAS No.: 71785-67-6
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Mol file: 71785-67-6.mol

Synonyms:(R)-2-Amino-2-(2-propenyl)propionsaeure-methylester

Chemical Property of (R)-2-Amino-2-(2-propenyl)propionsaeure-methylester

Chemical Property:

• Boiling Point: 154.1±28.0 °C(Predicted)
• Density: 0.978±0.06 g/cm3(Predicted)

Purity/Quality:

≥95% ^*data from raw suppliers

(R)-2-Amino-2-methyl-pent-4-enoicacidmethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Amino-2-(2-propenyl)propionsaeure-methylester

There total 11 articles about (R)-2-Amino-2-(2-propenyl)propionsaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpent-4-enoic acid (288617-71-0,288617-76-5) + diazomethyl-trimethyl-silane (18107-18-1) → (R)-2-Amino-2-(2-propenyl)propionsaeure-methylester (71785-67-6)

Guidance literature:

(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpent-4-enoic acid; diazomethyl-trimethyl-silane; In methanol; hexane; dichloromethane; for 1h;

With piperidine; In tetrahydrofuran; for 2h;

DOI:10.1021/acs.jmedchem.0c00100

Reference yield:

(3R,6S)-2,5-Dimethoxy-3,6-dimethyl-3-(2-propenyl)-3,6-dihydropyrazin (71785-61-0) → L-Alanine methyl ester (10065-72-2) + (R)-2-Amino-2-(2-propenyl)propionsaeure-methylester (71785-67-6)

Guidance literature:

With hydrogenchloride; Ambient temperature;

DOI:10.1016/S0040-4020(01)91926-X

Reference yield:

trimethoxonium tetrafluoroborate (420-37-1) + allyl bromide (106-95-6) → L-Alanine methyl ester (10065-72-2) + (R)-2-Amino-2-(2-propenyl)propionsaeure-methylester (71785-67-6) + (S)-2-Amino-2-(2-propenyl)propionsaeure-methylester (88820-87-5)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

(3R,6S)-2,5-Dimethoxy-3,6-dimethyl-3-(2-methylnaphthyl)-3,6-dihydropyrazin

methanol

C^α-methyl-D,L-allylglycinamide

trimethoxonium tetrafluoroborate

Refernces

• 1、 -. "COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PYRIDOPYRIMIDINE DERIVATIVES". Page/Page column 338; 339. . Retrieved 2021/01/22.
• 2、 -. "TOLL LIKE RECEPTOR MODULATOR COMPOUNDS". Paragraph 0868; 0869. . Retrieved 2016/10/27.