Technology Process of phenyl 2-azido-6-O-benzoyl-3-O-benzyl-2-deoxy-1-thio-β-D-glucopyranoside
There total 8 articles about phenyl 2-azido-6-O-benzoyl-3-O-benzyl-2-deoxy-1-thio-β-D-glucopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/jo300722y
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 18 h / 20 °C / Inert atmosphere
2.1: potassium carbonate; water / methanol / 18 h / 60 °C
3.1: imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate / methanol / 2.67 h / 20 °C
4.1: toluene-4-sulfonic acid / acetonitrile / 72 h / 20 °C
5.1: sodium hydride / tetrahydrofuran / 1.5 h / 20 °C
5.2: 3 h / 50 °C
6.1: water; acetic acid / 3 h / 100 °C
7.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere
With
imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; trimethylsilyl trifluoromethanesulfonate; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo300722y
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridine / dichloromethane / 16 h / 0 - 20 °C
2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 18 h / 20 °C / Inert atmosphere
3.1: potassium carbonate; water / methanol / 18 h / 60 °C
4.1: imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate / methanol / 2.67 h / 20 °C
5.1: toluene-4-sulfonic acid / acetonitrile / 72 h / 20 °C
6.1: sodium hydride / tetrahydrofuran / 1.5 h / 20 °C
6.2: 3 h / 50 °C
7.1: water; acetic acid / 3 h / 100 °C
8.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere
With
pyridine; imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; trimethylsilyl trifluoromethanesulfonate; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo300722y
