Benzonitrile,4-[2-(trans-4-pentylcyclohexyl)- ethyl]-

Base Information

• Chemical Name: Benzonitrile,4-[2-(trans-4-pentylcyclohexyl)- ethyl]-
• CAS No.: 84463-95-6
• Molecular Formula: C20H29N
• Molecular Weight: 283.457
• Mol file: 84463-95-6.mol

Synonyms:Benzonitrile,4-[2-(trans-4-pentylcyclohexyl)- ethyl]-;

Chemical Property of Benzonitrile,4-[2-(trans-4-pentylcyclohexyl)- ethyl]-

Chemical Property:

• PSA: 23.79000
• LogP: 5.87758

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzonitrile,4-[2-(trans-4-pentylcyclohexyl)- ethyl]-

There total 11 articles about Benzonitrile,4-[2-(trans-4-pentylcyclohexyl)- ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

4-[2-(4-Pentyl-cyclohexyl)-ethyl]-benzamide (89013-06-9) → p-[2-(trans-4-pentylcyclohexyl)ethyl]benzonitrile (84463-95-6)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide;

Reference yield:

4-trans-pentylcyclohexane-1-carboxylic acid (38289-29-1,38792-89-1,67589-84-8) → p-[2-(trans-4-pentylcyclohexyl)ethyl]benzonitrile (84463-95-6)

Guidance literature:

Multi-step reaction with 11 steps

1: 100 percent / SOCl₂

2: 91 percent / LiAlH₄ / diethyl ether

3: 76 percent / HBr, aq/H₂SO₄

4: 93 percent / dimethylsulfoxide

5: 78 percent / H₂SO₄ / acetic acid

6: 100 percent / SOCl₂

7: 75 percent / Friedel Crafts reaction

8: 69 percent / Huang-Minlon reduction

9: 73 percent / AlCl₃ / CH₂Cl₂

10: 65 percent / aq. NH₃

11: 52 percent / SOCl₂ / dimethylformamide

With ammonium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; sulfuric acid; hydrogen bromide; In diethyl ether; dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

trans-4-pentylcyclohexanecarboxamide (71458-08-7) → p-[2-(trans-4-pentylcyclohexyl)ethyl]benzonitrile (84463-95-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 76 percent / HBr, aq/H₂SO₄

2: 93 percent / dimethylsulfoxide

3: 78 percent / H₂SO₄ / acetic acid

4: 100 percent / SOCl₂

5: 75 percent / Friedel Crafts reaction

6: 69 percent / Huang-Minlon reduction

7: 73 percent / AlCl₃ / CH₂Cl₂

8: 65 percent / aq. NH₃

9: 52 percent / SOCl₂ / dimethylformamide

With ammonium hydroxide; aluminium trichloride; thionyl chloride; sulfuric acid; hydrogen bromide; In dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

4-[2-(4-Pentyl-cyclohexyl)-ethyl]-benzamide

4-trans-pentylcyclohexane-1-carboxylic acid

trans-4-pentylcyclohexanecarboxamide

trans-4-bromomethyl-1-n-pentylcyclohexane

Refernces