(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester

Base Information

• Chemical Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester
• CAS No.: 83478-32-4
• Molecular Formula: C₂₃H₂₅F₃O₃
• Molecular Weight: 406.445
• Mol file: 83478-32-4.mol

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester

Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester

There total 2 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4E)-2-methyl-2-phenyl-4-hexenoic acid (83541-10-0) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester (83478-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / Heating

2: pyridine / CH₂Cl₂ / Ambient temperature

With pyridine; lithium aluminium tetrahydride; In diethyl ether; dichloromethane;

DOI:10.1021/ja00389a054

Reference yield:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (2S,4E)-2-methyl-2-phenyl-4-hexen-1-ol (83478-44-8) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(S)-2-methyl-2-phenyl-hex-4-enyl ester (83478-32-4)

Guidance literature:

With pyridine; In dichloromethane; Ambient temperature;

DOI:10.1021/ja00389a054

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(2S,4E)-2-methyl-2-phenyl-4-hexen-1-ol

(2S,4E)-2-methyl-2-phenyl-4-hexenoic acid