1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one

Base Information

Chemical Name:1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one
CAS No.:1349723-17-6
Molecular Formula:C₁₅H₁₁BrClF₂NO₂
Molecular Weight:390.612
Hs Code.:

Synonyms:1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one

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Chemical Property of 1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one

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Technology Process of 1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one

There total 7 articles about 1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1349723-18-7
1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-ol

: 1349723-17-6
1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 40 ℃; for 8h;

Reference yield:

: 202925-07-3
2-chloro-1-fluoro-4-methoxybenzene

: 1349723-17-6
1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / isobutyl methyl ether; hexanes / 3 h / -78 °C

1.2: 0.75 h / -60 °C

2.1: tetrahydrofuran / 3 h / 0 - 20 °C

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 24 °C

4.1: N,N-dimethyl-formamide / 75 °C

5.1: diisobutylaluminium hydride / toluene; hexanes / 2.5 h / 0 - 5 °C

6.1: lithium diisopropyl amide / tetrahydrofuran / 0.58 h / -78 °C

6.2: 0.25 h / -78 °C

7.1: pyridinium chlorochromate / dichloromethane / 8 h / 40 °C

With n-butyllithium; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; hexanes; dichloromethane; isobutyl methyl ether; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1175301-75-3
1-(2-chloro-3-fluoro-6-methoxyphenyl)ethanol

: 1349723-17-6
1-(5-bromo-2-fluoropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 24 °C

2.1: N,N-dimethyl-formamide / 75 °C

3.1: diisobutylaluminium hydride / toluene; hexanes / 2.5 h / 0 - 5 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.58 h / -78 °C

4.2: 0.25 h / -78 °C

5.1: pyridinium chlorochromate / dichloromethane / 8 h / 40 °C

With diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; hexanes; dichloromethane; N,N-dimethyl-formamide; toluene;