2-Chloro-3-fluoro-6-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Chloro-3-fluoro-6-methoxybenzaldehyde
• CAS No.: 1263378-40-0
• Molecular Formula: C8H6ClFO2
• Molecular Weight: 188.586
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID001280908
• Mol file: 1263378-40-0.mol

Synonyms:2-chloro-3-fluoro-6-methoxybenzaldehyde;1263378-40-0;2-CHLORO-3-FLUORO-6-METHOXY-BENZALDEHYDE;SCHEMBL1358908;ZMHNXAZNZZEWIN-UHFFFAOYSA-N;DTXSID001280908;MFCD18432476;AKOS023627251;JS-5284;SB32490;CS-0340582

Chemical Property of 2-Chloro-3-fluoro-6-methoxybenzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 2.30020
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 188.0040353
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-3-fluoro-6-methoxybenzaldehyde 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)F)Cl)C=O

Technology Process of 2-Chloro-3-fluoro-6-methoxybenzaldehyde

There total 4 articles about 2-Chloro-3-fluoro-6-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloro-3,6-difluorobenzaldehyde (261762-39-4) → 2-chloro-3-fluoro-6-methoxy-benzaldehyde (1263378-40-0)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; at 60 ℃;

Reference yield: 72.0%

2-chloro-3,6-difluorobenzaldehyde (261762-39-4) + methanol (67-56-1) → 2-chloro-3-fluoro-6-methoxy-benzaldehyde (1263378-40-0)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/acs.jmedchem.5b01153

Reference yield: 68.0%

2-chloro-3,6-difluorobenzaldehyde (261762-39-4) + sodium methylate (124-41-4) → 2-chloro-3-fluoro-6-methoxy-benzaldehyde (1263378-40-0)

Guidance literature:

In tetrahydrofuran; methanol; at 60 ℃;

upstream raw materials:

Methyl formate

2-chloro-1-fluoro-4-methoxybenzene

2-chloro-3,6-difluorobenzaldehyde

methanol

Downstream raw materials:

5-bromo-3-[(2-chloro-3-fluoro-6-methoxyphenyl)-hydroxymethyl]-1H-pyrrolo[2,3-b]pyridine

trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

5-[1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-1H-pyrazol-4-yl]-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

C₃₁H₃₉ClF₂N₄O₂Si