(4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride

Base Information

Chemical Name:(4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride
CAS No.:1400670-01-0
Molecular Formula:C₂₃H₂₄ClN₇*ClH
Molecular Weight:470.404
Hs Code.:

Synonyms:(4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride

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Chemical Property of (4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride

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Technology Process of (4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride

There total 5 articles about (4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.1%

: 1400670-29-2
3-(6-bromo-pyridin-2-yl)-8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazine

: 104-86-9
4-chlorobenzylamine

: 1400670-01-0
(4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride

Guidance literature:: 3-(6-bromo-pyridin-2-yl)-8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazine; 4-chlorobenzylamine; With sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 15h; Inert atmosphere;

With hydrogenchloride;

Reference yield:

: 34160-40-2
6-bromo-2-pyridinecarbaldehyde

: 1400670-01-0
(4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -10 °C

1.2: 12 h / 20 °C

2.1: N-Bromosuccinimide / 0.5 h / 0 °C

3.1: toluene-4-sulfonic acid / acetonitrile; water / Reflux

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / Reflux

5.1: DavePhos; sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 100 °C / Inert atmosphere

With N-Bromosuccinimide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; DavePhos; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1400670-01-0
(4-chlorobenzyl)-{6-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyridin-2-yl}amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / Reflux

2: DavePhos; sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 100 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; isopropyl alcohol;