t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate

Base Information

Chemical Name:t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate
CAS No.:1435943-08-0
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:377.44
Hs Code.:

Synonyms:t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate

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Chemical Property of t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate

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Technology Process of t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate

There total 3 articles about t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1112238-37-5
(E)-tert-butyl 2-oxo-4-phenylbut-3-enoate

: 614-16-4
Benzoylacetonitrile

: 1435943-08-0
t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate

Guidance literature:: With C₃₆H₅₀N₄O₄; 4-(1,1-dimethylethyl)benzoic acid; In tert-butyl methyl ether; at -30 ℃; for 72h; Molecular sieve; Inert atmosphere;
DOI:10.1021/ol400894j

Reference yield:

: 100-52-7
benzaldehyde

: 1435943-08-0
t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 16 h / 10 - 40 °C / Inert atmosphere

2: acetyl chloride / 8 h / 0 °C / Reflux

3: C₃₆H₅₀N₄O₄; 4-(1,1-dimethylethyl)benzoic acid / tert-butyl methyl ether / 72 h / -30 °C / Molecular sieve; Inert atmosphere

With C₃₆H₅₀N₄O₄; acetyl chloride; 4-(1,1-dimethylethyl)benzoic acid; potassium hydroxide; In methanol; tert-butyl methyl ether; 1: |Aldol Condensation / 3: |Michael Addition;
DOI:10.1021/ol400894j

Reference yield:

: 140653-89-0
(E)-benzylideneglyoxylic acid potassium salt

: 1435943-08-0
t-butyl 5-cyano-2-hydroxy-4,6-diphenyl-3,4-dihydro-2H-pyran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetyl chloride / 8 h / 0 °C / Reflux

2: C₃₆H₅₀N₄O₄; 4-(1,1-dimethylethyl)benzoic acid / tert-butyl methyl ether / 72 h / -30 °C / Molecular sieve; Inert atmosphere

With C₃₆H₅₀N₄O₄; acetyl chloride; 4-(1,1-dimethylethyl)benzoic acid; In tert-butyl methyl ether; 2: |Michael Addition;
DOI:10.1021/ol400894j