(S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol

Base Information

• Chemical Name: (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol
• CAS No.: 122172-26-3
• Molecular Formula: C₁₈H₂₆O₂S₄
• Molecular Weight: 402.667

Synonyms:(S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol

Chemical Property of (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol

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Technology Process of (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol

There total 2 articles about (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-2-[1,3]Dithiolan-2-yl-2-(4-methoxy-phenyl)-4-(2-methyl-[1,3]dithiolan-2-yl)-butyric acid (1S,2R,3R,4S)-4,7,7-trimethyl-3-naphthalen-1-yl-bicyclo[2.2.1]hept-2-yl ester (122172-25-2) → (4S)-3-exo-(1-naphthyl)-4,7,7-trimethylbicyclo[2.2.1]heptan-2-exo-ol (86835-18-9) + (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol (122172-26-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h;

DOI:10.1021/jo00277a017

Reference yield:

(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate (122172-24-1) → (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol (122172-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / zinc triflate / petroleum ether / 1.5 h / Ambient temperature

2: 90 percent / LiAlH₄ / tetrahydrofuran / 0.5 h

With lithium aluminium tetrahydride; zinc trifluoromethanesulfonate; In tetrahydrofuran; Petroleum ether;

DOI:10.1021/jo00277a017

Reference yield: 68.0%

(S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol (122172-26-3) → (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butanal (122172-27-4)

Guidance literature:

With dipyridinium dichromate; sodium acetate; In dichloromethane; at 0 ℃; for 6h;

DOI:10.1021/jo00277a017

upstream raw materials:

(S)-2-[1,3]Dithiolan-2-yl-2-(4-methoxy-phenyl)-4-(2-methyl-[1,3]dithiolan-2-yl)-butyric acid (1S,2R,3R,4S)-4,7,7-trimethyl-3-naphthalen-1-yl-bicyclo[2.2.1]hept-2-yl ester

(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

Downstream raw materials:

(S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butanal

(S)-4-(4-methoxyphenyl)-4-<2-(phenylmethoxy)eth-1-yl>cyclohex-2-en-1-one

(R)-3-(4-methoxyphenyl)-3-<2-(1,3-dithiolanyl)>-5-<2-(2-methyl-1,3-dithiolanyl)>pentan-1-al

(R)-3-[1,3]Dithiolan-2-yl-3-(4-methoxy-phenyl)-5-(2-methyl-[1,3]dithiolan-2-yl)-pentan-1-ol

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