N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride

Base Information

Chemical Name:N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride
CAS No.:1612893-79-4
Molecular Formula:C₁₈H₁₄N₆O₂*ClH
Molecular Weight:382.809
Hs Code.:

Synonyms:N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride

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Chemical Property of N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride

There total 6 articles about N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1612893-55-6
5-(4-guanidinophenyl)isoxazole-3-carboxylic acid hydrochloride

: 873-74-5
4-Aminobenzonitrile

: 1612893-79-4
N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2014.04.118

Reference yield:

: 54808-56-9
4-(4-nitrophenyl)-2,4-dione-butyric acid ethyl ester

: 1612893-79-4
N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride / ethanol / 4 h / Reflux

2: tin(II) chloride dihdyrate / ethyl acetate / 6 h / Reflux

3: hydrogenchloride / ethanol; water / 8 h / Reflux

4: sodium hydroxide / water; methanol / 3 h / Reflux

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dimethyl sulfoxide / 48 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.bmcl.2014.04.118

Reference yield:

: 159670-70-9
ethyl 5-(4-nitrophenyl)isoxazole-3-carboxylate

: 1612893-79-4
N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate / ethyl acetate / 6 h / Reflux

2: hydrogenchloride / ethanol; water / 8 h / Reflux

3: sodium hydroxide / water; methanol / 3 h / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dimethyl sulfoxide / 48 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.bmcl.2014.04.118