159670-70-9

Basic information

• Product Name: 3-(4-NITRO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 3-(4-NITRO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 159670-70-9
• Molecular Formula: C₁₂H₁₀N₂O₅
• Molecular Weight: 262.2182
• Mol File: 159670-70-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-NITRO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-NITRO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(159670-70-9)
• EPA Substance Registry System: 3-(4-NITRO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(159670-70-9)

Safety Data

• Hazardous Substances Data: 159670-70-9(Hazardous Substances Data)

Upstream product

• 95080-93-6 ethyl chlorooximidoacetate 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 623-33-6 glycine ethyl ester hydrochloride 
• 98-86-2 acetophenone 
• 100-19-6 (4-nitrophenyl)ethanone 
• 54808-56-9 4-(4-nitrophenyl)-2,4-dione-butyric acid ethyl ester 
• 18456-68-3 cis-2-(p-nitrohenyl)cyclopropanecarboxylic acid ethyl ester 
• 1206479-02-8 ethyl 5-(4-nitrophenyl)-4,5-dihydroisoxazole-3-carboxylate 
• 75867-38-8 4-nitro-1-(trimethylsilylethynyl)benzene 
• 52313-46-9 ethyl 2-acetyl-4-oxo-4-phenylbutanoate 
• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 
• 17763-80-3 para-nitrophenyl triflate 

Downstream Products

• 1612893-55-6 5-(4-guanidinophenyl)isoxazole-3-carboxylic acid hydrochloride 
• 1612893-63-6 ethyl 4-(5-(4-guanidinophenyl)isoxazole-3-carboxamido)benzoate hydrochloride 
• 1612893-65-8 5-(4-Guanidinophenyl)-N-p-tolylisoxazole-3-carboxamide hydrochloride 
• 1612893-66-9 N-(2,6-dimethylphenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride 
• 1612893-69-2 N-(3-bromophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride 
• 1612893-70-5 5-(4-guanidinophenyl)-N-(o-tolyl)isoxazole-3-carboxamide hydrochloride 
• 1613109-50-4 5-(4-guanidinophenyl)-N-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1612893-73-8 N-(4-chlorophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride 
• 908802-68-6 ethyl 5-(4-amino-phenyl)isoxazole-3-carboxylate 
• 1612893-77-2 5-(4-guanidinophenyl)-N-(naphthalen-1-yl)isoxazole-3-carboxamide hydrochloride 
• 1612893-78-3 5-(4-guanidinophenyl)-N-(m-tolyl)isoxazole-3-carboxamide hydrochloride 
• 1612893-79-4 N-(4-cyanophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide hydrochloride 
• 1613109-58-2 N-(2,3-dimethylphenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide 
• 1613109-59-3 N-(4-fluorophenyl)-5-(4-guanidinophenyl)isoxazole-3-carboxamide 

Relevant articles and documents

Synthesis of isoxazoles via cyclization of β-fluoro enones with sodium azide

A practical method for the synthesis of 3,5-disubstituted isoxazoles via cyclization of β-fluoro enones with sodium azide was disclosed. Density functional theory (DFT) calculation indicated that both (1) the azirine formation followed by intramolecular rearrangement and (2) direct enolate O-attack via 5-exo-trig cyclization of vinyl azide were possible for the isoxazole formation.

Oxidize Amines to Nitrile Oxides: One Type of Amine Oxidation and Its Application to Directly Construct Isoxazoles and Isoxazolines

A facile oxidative heterocyclization of commercially available amines and tert-butyl nitrite with alkynes or alkenes leading to isoxazoles or isoxazolines is described. The unprecedented strategy of the oxidation of an amine directly to a nitrile oxide was used in this cyclization process. This reaction is highly efficient, regiospecific, operationally simple, mild, and tolerant of a variety of functional groups. Control experiments support a nitrile oxide intermediate mechanism for this novel class of oxidative cyclization reactions. Moreover, synthetic applications toward bioactive molecular skeletons and the late-stage modification of drugs were realized.

Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated with Alzheimer's Disease

A novel series of hybrid arylisoxazole-chromenone carboxamides were designed, synthesized, and evaluated for their cholinesterase (ChE) inhibitory activity based on the modified Ellman's method. Among synthesized compounds, 5-(3-nitrophenyl)-N-{4-[(2-oxo-