N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide
CAS No.:1616244-81-5
Molecular Formula:C₄₀H₃₇FN₆O₇
Molecular Weight:732.768
Hs Code.:

N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide

Synonyms:N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide

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Chemical Property of N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide

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Technology Process of N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide

There total 12 articles about N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1290538-61-2
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

: 1616244-87-1
C₁₅H₈ClN₃O₄

: 1616244-81-5
N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1016/j.bmc.2014.05.013

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 1616244-81-5
N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / acetone / 20 °C

2: nitric acid / dichloromethane / 4 h / 0 °C

3: nitric acid / toluene / 10 h / 110 °C

4: iron / acetic acid / 2 h / 80 °C

5: acetonitrile / 10 h / 85 °C

6: trichlorophosphate / acetonitrile / 6 h / 85 °C

7: chlorobenzene / 30 h / 140 °C

8: iron; ammonium chloride / ethanol

9: triethylamine / dichloromethane / 10 h / 20 °C

With nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; trichlorophosphate; In ethanol; dichloromethane; acetic acid; chlorobenzene; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.05.013

Reference yield:

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 1616244-81-5
N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-3-(4-nitro phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / dichloromethane / 4 h / 0 °C

2: nitric acid / toluene / 10 h / 110 °C

3: iron / acetic acid / 2 h / 80 °C

4: acetonitrile / 10 h / 85 °C

5: trichlorophosphate / acetonitrile / 6 h / 85 °C

6: chlorobenzene / 30 h / 140 °C

7: iron; ammonium chloride / ethanol

8: triethylamine / dichloromethane / 10 h / 20 °C

With nitric acid; iron; ammonium chloride; triethylamine; trichlorophosphate; In ethanol; dichloromethane; acetic acid; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.05.013