3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Base Information

Chemical Name:3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine
CAS No.:1290538-61-2
Molecular Formula:C₂₅H₃₀FN₃O₃
Molecular Weight:439.53
Hs Code.:

Synonyms:3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Suppliers and Price of 3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

There total 15 articles about 3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1436418-01-7
4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

: 1290538-61-2
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Guidance literature:: With ammonium chloride; zinc; In ethanol; water; for 3h; Reflux;
DOI:10.1021/acs.jmedchem.8b00672

Reference yield:

: 1160707-44-7
1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

: 1290538-61-2
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 10 h / 110 °C

2: acetic acid / 2 h / 60 - 80 °C

3: acetonitrile / 10 h / 85 °C

4: trichlorophosphate / acetonitrile / 6 h / 85 °C

5: chlorobenzene / 30 h / 140 °C

6: ammonium chloride; iron / ethanol; water / 5 h / Reflux

With iron; ammonium chloride; trichlorophosphate; In ethanol; water; acetic acid; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.04.013

Reference yield:

: 1394166-09-6,1428788-16-2
6-methyloxy-7-(4-(3-chloropropoxy))-4-4-hydroxyquinoline

: 1290538-61-2
3-fluoro-4-{6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yloxy}phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 10 h / 85 °C

2: trichlorophosphate / acetonitrile / 6 h / 85 °C

3: chlorobenzene / 30 h / 140 °C

4: ammonium chloride; iron / ethanol; water / 5 h / Reflux

With iron; ammonium chloride; trichlorophosphate; In ethanol; water; chlorobenzene; acetonitrile;
DOI:10.1016/j.bmc.2013.04.013