(2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal

Base Information

Chemical Name:(2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal
CAS No.:570383-48-1
Molecular Formula:C₃₂H₃₈N₂O₂
Molecular Weight:482.666
Hs Code.:

Synonyms:(2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal

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Chemical Property of (2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal

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Technology Process of (2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal

There total 6 articles about (2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Dibenzyl-[(S)-1-[(E)-benzylimino-methyl]-2-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-ethyl]-amine

: 570383-48-1
(2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 4h;
DOI:10.1016/S0040-4020(03)00309-0

Reference yield:

: 100-39-0
benzyl bromide

: 570383-48-1
(2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal

Guidance literature:: Multi-step reaction with 6 steps

1.1: Li; NH₃ / ethanol / -78 °C

1.2: 69 percent / K₂CO₃ / ethanol / 7 h / Heating

2.1: 73 percent / BF₃*Et₂O / tetrahydrofuran / 0 °C

3.1: LiAlH₄ / diethyl ether / 20 °C

4.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 °C

5.1: MgSO₄ / CH₂Cl₂ / 4 h / 20 °C

6.1: 470 mg / NaBH₄ / methanol / 4 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; ammonia; lithium; magnesium sulfate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 1.1: Birch reduction / 4.1: Swern oxidation;
DOI:10.1016/S0040-4020(03)00309-0

Reference yield:

: 570383-63-0
(2S)-2-dibenzylamino-3-(4-methoxy-2,5-dihydrophenyl)propionic acid

: 570383-48-1
(2S)-N-benzyl-2-(N,N-dibenzylamino)-3-(4-oxocyclohex-1-enyl)propanamine ethylene acetal

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / BF₃*Et₂O / tetrahydrofuran / 0 °C

2: LiAlH₄ / diethyl ether / 20 °C

3: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 °C

4: MgSO₄ / CH₂Cl₂ / 4 h / 20 °C

5: 470 mg / NaBH₄ / methanol / 4 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; magnesium sulfate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 3: Swern oxidation;
DOI:10.1016/S0040-4020(03)00309-0