(+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one

Base Information

Chemical Name:(+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one
CAS No.:1144042-90-9
Molecular Formula:C₂₅H₂₀F₂N₂O₃
Molecular Weight:434.442
Hs Code.:

Synonyms:(+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one

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Technology Process of (+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one

There total 4 articles about (+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1144042-97-6
C₂₉H₂₉N₃O₄S

: 144025-03-6
2,4-difluorophenylboronic acid

: 1144043-13-9
2-(2,4-difluorophenylthio)-N-isopropylbenzamide

: 1144042-90-9
(+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one

Guidance literature:: With copper(I) 2-hydroxy-3-methylbenzoate; oxygen; In N,N-dimethyl-formamide; at 23 ℃; for 3h; optical yield given as %ee;
DOI:10.1002/anie.200804524

Reference yield: 76.0%

: 1144042-80-7
C₃₀H₃₁N₃O₄S

: 144025-03-6
2,4-difluorophenylboronic acid

: C₁₇H₁₇F₂NOS

: 1144042-90-9
(+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one

Guidance literature:: With copper(I) 2-hydroxy-3-methylbenzoate; oxygen; In N,N-dimethyl-formamide; at 23 ℃; for 6h;
DOI:10.1002/anie.200804524

Reference yield: 71.0%

: 1144043-02-6
C₂₇H₂₅N₃O₄S

: 144025-03-6
2,4-difluorophenylboronic acid

: C₁₄H₁₁F₂NOS

: 1144042-90-9
(+)-(S)-2-(benzyloxycarbonylamino)-1-(2,4-difluorophenyl)-3-(1H-indol-3-yl)propan-1-one

Guidance literature:: With copper(I) 2-hydroxy-3-methylbenzoate; oxygen; In N,N-dimethyl-formamide; at 23 ℃; for 6h;
DOI:10.1002/anie.200804524