1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione

Base Information

Chemical Name:1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione
CAS No.:317332-32-4
Molecular Formula:C₂₇H₂₃N₃O₂
Molecular Weight:421.499
Hs Code.:

Synonyms:1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione

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Chemical Property of 1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione

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Technology Process of 1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione

There total 10 articles about 1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13509-13-2
4-methylpyridine-2-carboxylic acid methyl ester

: 251966-69-5
3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone

: 317332-32-4
1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione

Guidance literature:: 3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.75h;

4-methylpyridine-2-carboxylic acid methyl ester; at -78 - 20 ℃; for 2h;

Reference yield:

: 317334-33-1
(3-benzyl-5-bromophenyl) pyrazin-2-yl ketone

: 317332-32-4
1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine / ethylene glycol / 4 h / 110 °C

2.1: potassium hydroxide / ethylene glycol / 4 h / 160 °C

3.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

3.2: 3 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexanes / 0.75 h / -78 °C

4.2: 2 h / -78 - 20 °C

With potassium hydroxide; n-butyllithium; -butyl vinyl ether; triethylamine; hydrazine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; hexanes; DMF (N,N-dimethyl-formamide); ethylene glycol;

Reference yield:

: 317334-34-2
3-benzyl-5-pyrazin-2-ylmethyl-1-bromobenzene

: 317332-32-4
1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

1.2: 3 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.75 h / -78 °C

2.2: 2 h / -78 - 20 °C

With n-butyllithium; -butyl vinyl ether; triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; hexanes; DMF (N,N-dimethyl-formamide);