Technology Process of 1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione
There total 10 articles about 1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone;
With
n-butyllithium;
In
tetrahydrofuran; hexanes;
at -78 ℃;
for 0.75h;
4-methylpyridine-2-carboxylic acid methyl ester;
at -78 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrazine / ethylene glycol / 4 h / 110 °C
2.1: potassium hydroxide / ethylene glycol / 4 h / 160 °C
3.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C
3.2: 3 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexanes / 0.75 h / -78 °C
4.2: 2 h / -78 - 20 °C
With
potassium hydroxide; n-butyllithium; -butyl vinyl ether; triethylamine; hydrazine;
1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
tetrahydrofuran; hexanes; DMF (N,N-dimethyl-formamide); ethylene glycol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C
1.2: 3 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.75 h / -78 °C
2.2: 2 h / -78 - 20 °C
With
n-butyllithium; -butyl vinyl ether; triethylamine;
1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
tetrahydrofuran; hexanes; DMF (N,N-dimethyl-formamide);