3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone

Base Information

Chemical Name:3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone
CAS No.:251966-69-5
Molecular Formula:C₂₀H₁₈N₂O
Molecular Weight:302.376
Hs Code.:

Synonyms:3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone

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Chemical Property of 3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone

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Technology Process of 3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone

There total 7 articles about 3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 317334-33-1
(3-benzyl-5-bromophenyl) pyrazin-2-yl ketone

: 251966-69-5
3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine / ethylene glycol / 4 h / 110 °C

2.1: potassium hydroxide / ethylene glycol / 4 h / 160 °C

3.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

3.2: 3 h / 20 °C

With potassium hydroxide; -butyl vinyl ether; triethylamine; hydrazine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In DMF (N,N-dimethyl-formamide); ethylene glycol;

Reference yield:

: C₁₈H₁₅BrN₄

: 251966-69-5
3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethylene glycol / 4 h / 160 °C

2.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

2.2: 3 h / 20 °C

With potassium hydroxide; -butyl vinyl ether; triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In DMF (N,N-dimethyl-formamide); ethylene glycol;

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 251966-69-5
3-Benzyl-5-1-pyrazin-2-ylmethylacetophenone

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexanes; diethyl ether / 0.5 h / -78 °C

1.2: -78 - 0 °C

2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 20 °C

3.1: hexanes; diethyl ether / 1 h / -78 °C

3.2: 20 °C

4.1: hydrazine / ethylene glycol / 4 h / 110 °C

5.1: potassium hydroxide / ethylene glycol / 4 h / 160 °C

6.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

6.2: 3 h / 20 °C

With triethylsilane; potassium hydroxide; n-butyllithium; -butyl vinyl ether; boron trifluoride diethyl etherate; triethylamine; hydrazine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In hexanes; DMF (N,N-dimethyl-formamide); diethyl ether; dichloromethane; ethylene glycol;