2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Base Information

Chemical Name:2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one
CAS No.:528859-40-7
Molecular Formula:C₂₅H₂₆FN₃O₃
Molecular Weight:435.498
Hs Code.:

Synonyms:2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

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Chemical Property of 2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

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Technology Process of 2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

There total 6 articles about 2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 528859-36-1
2-(1-methyl-1-hydroxycarbonylethyl)-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

: 528859-40-7
2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: With borane; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm0205402

Reference yield:

: 38923-57-8
methyl 2,2-dimethyl-3-oxobutanoate

: 528859-40-7
2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: Br₂; AlCl₃ / diethyl ether / 0 - 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 76 percent / dimethylformamide / 20 °C

3.1: 58 percent / TBAF / 1,2-dichloro-ethane; tetrahydrofuran

4.1: 51 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene / 6 h / 110 °C

5.1: 83 percent / aq. KOH / methanol / 4 h / 50 °C

6.1: 69 percent / BH₃ / tetrahydrofuran / 2 h / 20 °C

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium trichloride; borane; tetrabutyl ammonium fluoride; bromine; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 4.1: Suzuki coupling;
DOI:10.1021/jm0205402

Reference yield:

: 84691-57-6
4-bromo-2,2-dimethyl acetoacetic acid methyl ester

: 528859-40-7
2-(1,1-dimethyl-2-hydroxy)ethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 76 percent / dimethylformamide / 20 °C

2.1: 58 percent / TBAF / 1,2-dichloro-ethane; tetrahydrofuran

3.1: 51 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene / 6 h / 110 °C

4.1: 83 percent / aq. KOH / methanol / 4 h / 50 °C

5.1: 69 percent / BH₃ / tetrahydrofuran / 2 h / 20 °C

With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 3.1: Suzuki coupling;
DOI:10.1021/jm0205402