38923-57-8

Basic information

• Product Name: METHYL 2,2-DIMETHYLACETOACETATE
• Synonyms: METHYL 2,2-DIMETHYL-3-OXOBUTANOATE;METHYL 2,2-DIMETHYLACETOACETATE;2,2-Dimethyl-3-oxobutyric acid, methyl ester;Butanoic acid, 2,2-dimethyl-3-oxo-, methyl ester;2,2-Dimethyl-3-oxobutanoic acid methyl ester;2,2-DiMethyl-3-oxobutyric acid;Methyl 2,2-dimethyl-3-oxobutyrate
• CAS NO: 38923-57-8
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• EINECS: 254-189-1
• Mol File: 38923-57-8.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 72-74°C 15mm
• Flash Point: 72-74°C/15mm
• Appearance: Liquid
• Density: 0,999 g/cm3
• Vapor Pressure: 1.58mmHg at 25°C
• Refractive Index: 1.4205
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• BRN: 1753940
• CAS DataBase Reference: METHYL 2,2-DIMETHYLACETOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2,2-DIMETHYLACETOACETATE(38923-57-8)
• EPA Substance Registry System: METHYL 2,2-DIMETHYLACETOACETATE(38923-57-8)

Safety Data

• Safety Statements: S23:Do not inhale gas/fumes/vapour/spray.; S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 38923-57-8(Hazardous Substances Data)

Usage

Uses

Pyrimidine was synthesis from methyl 2, 2-dimethylacetoacetate.

Synthesis Reference(s)

Synthetic Communications, 12, p. 829, 1982 DOI: 10.1080/00397918208065959

InChI:InChI=1/C7H12O3/c1-5(8)7(2,3)6(9)10-4/h1-4H3

Upstream product

• 141-52-6 sodium ethanolate 
• 141-97-9 ethyl acetoacetate 
• 74-88-4 methyl iodide 
• 105-45-3 acetoacetic acid methyl ester 
• 909874-50-6 2,2'-dimethyl-3,3'-ethanediyldiamino-di-crotonic acid dimethyl ester 
• 62936-03-2 3-Oxo-2,2-dimethyl-dithiobuttersaeure-methylester 
• 112818-16-3 methyl 2-(iodomethyl)-2-methyl-3-oxobutanoate 
• 74-83-9 methyl bromide 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 75-36-5 acetyl chloride 
• 23426-63-3 2-bromo-2-methylpropionic acid methyl ester 
• 7487-94-7 mercury (II) chloride 
• 17094-21-2 2-methyl-acetoacetic acid methyl ester 
• 563-80-4 3-methyl-butan-2-one 

Downstream Products

• 56663-74-2 methyl 3-chloro-2,2-dimethylbut-3-enoate 
• 79902-87-7 2,2-Dimethyl-3-phenylsilanyloxy-butyric acid methyl ester 
• 79891-91-1 3-[(2-Methoxycarbonyl-1,2-dimethyl-propoxy)-phenyl-silanyloxy]-2,2-dimethyl-butyric acid methyl ester 
• 547-63-7 Methyl isobutyrate 
• 4168-01-8 2,2,3-trimethyl-3-butenoic acid 
• 57690-96-7 2,2-dimethylbut-3-enoyl chloride 
• 19757-86-9 methyl 2,2-dimethyl-3-pentenoate 
• 211696-55-8 2,2-Dimethyl-but-3-enoic acid (2-chloro-benzyl)-hydroxy-amide 
• 211696-56-9 2,2,3-Trimethyl-but-3-enoic acid (2-chloro-benzyl)-hydroxy-amide 
• 1198227-67-6 C₂₁H₃₄O₆Si 

Relevant articles and documents

Process for the alkylation of active methylene compounds

The invention discloses an alkylation method of an active methylene compound. The method comprises the following steps: A, adding the active methylene compound to an inorganic alkali-first polar organic solvent mixing system to form a to-be-reacted mixture; B, adding an alkylating agent to the to-be-reacted mixture, filtering after reacting to obtain filtrate, and removing a solvent in the filtrate to obtain the alkylated active methylene compound. According to the method, the inorganic alkali is adopted as a proton abstraction reagent of the active methylene compound, so that the removal effect on alpha-hydrogen in the active methylene compound can be ensured, the alkylation reaction of the active methylene compound can be carried out under a mild condition, and the reaction safety is improved. Meanwhile, the inorganic alkali is low in price, so that the production cost of the alkylation reaction is reduced.

PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES

Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Titanium silicates as efficient catalyst for alkylation and acylation of silyl enol ethers under liquid-phase conditions

The activity of titanium- and tin-silicate samples such as TS-1, TS-2, Ti-β and Sn-MFI has been investigated for acylation and alkylation of silyl enol ethers under mild liquid-phase conditions. Silyl enol ethers successfully react with acetyl chloride and tert-butyl chloride under dry conditions in the presence of above catalysts to produce the corresponding acylated and alkylated products, respectively. In the case of acetylation reaction, two different nucleophiles with carbon-center (C-atom) and oxygen-center (O-atom) in silyloxy group of silyl enol ether reacts with acetyl chloride to give 1,3-diketone and ketene-ester, respectively. The selectivity for alkylation is always ca. 100% and no side products are formed. Among the various solvents investigated, anhydrous THF was found to be the suitable solvent for alkylation; whereas dichloromethane exhibited high selectivity for diketones for acylation. The formation of nucleophiles from silyl enol ethers appears to be the key step for successful acetylation and tert-butylation by nucleophilic reaction mechanism. Sn-MFI showed less activity than that observed over the titanosilicates. The observed catalytic activity is explained on the basis of "oxophilic Lewis acidity" of titanium silicate molecular sieves in the absence of H 2O under dry reaction conditions.