(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride

Base Information

Chemical Name:(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride
CAS No.:1313378-51-6
Molecular Formula:C₂₅H₂₁ClFN₅O₂*ClH
Molecular Weight:514.386
Hs Code.:

Synonyms:(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride

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Chemical Property of (E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride

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Technology Process of (E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride

There total 2 articles about (E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1313378-51-6
(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride

Guidance literature:

Reference yield: 67.0%

: 1245710-86-4
{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester

: 1313378-51-6
(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃;
DOI:10.1016/j.bmc.2010.08.004

Reference yield: 37.0%

: 894793-02-3
2-[18F]fluoroethylazide

: 1313378-51-6
(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride

: 1245711-08-3
C₂₇H₂₅ClF⁽¹⁸⁾FN₈O₂

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; acetonitrile; at 80 ℃; for 0.25h; pH=6; sodium phosphate buffer;
DOI:10.1016/j.bmc.2010.08.004