{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester

Base Information

• Chemical Name: {(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester
• CAS No.: 1245710-86-4
• Molecular Formula: C₃₀H₂₉ClFN₅O₄
• Molecular Weight: 578.043
• Mol file: 1245710-86-4.mol

Synonyms:{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester

Chemical Property of {(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester

There total 2 articles about {(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(E)-4-(tert-butoxycarbonyl-(prop-2-ynyl)amino)-but-2-enoic acid methyl ester (1264191-69-6) + 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile (361162-95-0) → {(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester (1245710-86-4)

Guidance literature:

With trimethylaluminum; In hexane; dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2010.08.004

Reference yield: 68.0%

→ {(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester (1245710-86-4)

Guidance literature:

Reference yield: 100.0%

{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester (1245710-86-4) → (E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide (1263387-04-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water;

DOI:10.1002/jlcr.3170

upstream raw materials:

(E)-4-(tert-butoxycarbonyl-(prop-2-ynyl)amino)-but-2-enoic acid methyl ester

6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile

Downstream raw materials:

{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}-[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-carbamic acid tert-butyl ester

(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide hydrochloride

(E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride

tert-butyl N-[(2E)-3-({4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}carbamoyl)prop-2-en-1-yl]-N-({1-[3-fluoro-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)carbamate