1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole

Base Information

Chemical Name:1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole
CAS No.:1338216-10-6
Molecular Formula:C₁₇H₁₄F₃N₃O₃S
Molecular Weight:397.378
Hs Code.:

Synonyms:1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole

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Technology Process of 1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole

There total 3 articles about 1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1338216-08-2
C₁₈H₁₆F₃N₃O₃S

: 1338216-10-6
1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole

Guidance literature:: With sodium thioethylate; In N,N-dimethyl-formamide; at 120 ℃; for 3h;
DOI:10.1016/j.bmcl.2011.08.053

Reference yield:

: 1338216-03-7
C₁₂H₁₁F₃O₃

: 1338216-10-6
1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 24 h / Reflux

2: sodium thioethylate / N,N-dimethyl-formamide / 3 h / 120 °C

With sodium thioethylate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.053

Reference yield:

: 3556-81-8
1-(3-methoxy-4-methylphenyl)ethan-1-one

: 1338216-10-6
1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-hydroxy-4-methylphenyl)pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol; tert-butyl methyl ether / 0.08 h

1.2: 24 h / Reflux

2.1: ethanol / 24 h / Reflux

3.1: sodium thioethylate / N,N-dimethyl-formamide / 3 h / 120 °C

With sodium methylate; sodium thioethylate; In methanol; ethanol; tert-butyl methyl ether; N,N-dimethyl-formamide; 1.1: Claisen condensation / 1.2: Claisen condensation;
DOI:10.1016/j.bmcl.2011.08.053