3556-81-8

Usage

Physical state

Pale yellow liquid

Odor

Sweet and floral

Usage

Fragrance industry (synthetic fragrance ingredient)

Applications

Perfumes, colognes, and other scented products

Additional use

Production of flavors for food and beverages

Potential properties

Antimicrobial and antifungal

Industrial applications

Versatile compound with various uses in different industries

Upstream product

• 3556-60-3 3-methoxy-4-methylcyano-benzene 
• 676-58-4 methylmagnesium chloride 
• 75-16-1 methylmagnesium bromide 
• 135754-83-5 N,3-dimethoxy-N,4-dimethylbenzamide 
• 68233-86-3 (3-Methoxy-4-methylphenyl)-methylcarbinol 
• 77-78-1 dimethyl sulfate 
• 917-54-4 methyllithium 
• 79744-80-2 3-methoxy-4-methylbenzoic acid lithium salt 
• 6379-73-3 carvacrol methyl ether 
• 33414-49-2 1-(3-hydroxy-4-methylphenyl)ethanone 
• 74-88-4 methyl iodide 
• 4685-50-1 3-methoxy-4-methylbenzyl alcohol 
• 24973-22-6 3-methoxy-4-methylbenzaldehyde 
• 7151-68-0 3-methoxy-p-toluic acid 

Downstream Products

• 92501-14-9 4-[(3-methoxy-4-methyl-phenyl)-thioacetyl]-morpholine 
• 59684-62-7 Xanthorrhizol 
• 113706-54-0 13-hydroxyxanthorrhizol 
• 1244612-53-0 ethyl 3-(3-methoxy-4-methylphenyl)-3-oxopropanoate 
• 1338216-16-2 1-(4-aminosulfonylphenyl)-3-trifluoromethyl-5-(3-acetoxy-4-methylphenyl)pyrazole 
• 1338216-24-2 C₁₈H₁₅F₃N₂OS 
• 1338216-08-2 C₁₈H₁₆F₃N₃O₃S 
• 1338216-30-0 1-(4-methylsulfonylphenyl)-3-trifluoromethyl-5-(3-acetoxy-4-methylphenyl)pyrazole 

Relevant academic research and scientific papers

THIADIAZINE DERIVATIVES

The invention relates to thiadiazine derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containing

INHIBITORS OF NHE-MEDIATED ANTIPORT

The present disclosure is directed to compounds (Ι') and to their use in methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds (Ι') and their use in methods for the treatment of hypertension. The present disclosure is also directed to compounds (Ι') and to their use in methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

Efficient total synthesis of racemic bisabolane sesquiterpenes curcuphenol and xanthorrhizol starting from substituted acetophenones

A total synthesis of natural bisabolane sesquiterpenes curcuphenol (1) and xanthorrhizol (2) was developed by using the substituted acetophenones 4 and 5, respectively, as starting materials. The acetyl group of the latter was activated through ethoxycarb

Baker's yeast-mediated enantioselective synthesis of the bisabolane sesquiterpenes (+)-curcuphenol, (+)-xanthorrhizol, (-)-curcuquinone and (+)-curcuhydroquinone

Fermenting baker's yeast converts the unsaturated aldehydes 5a-c into the saturated alcohols 6a-c, respectively. The microbial saturation of substrates adsorbed on a nonpolar resin proceeds in high chemical yields and shows complete enantioselectivity in the formation of the (S)-(+) isomers. Enantiopure 6a-c are versatile chiral building blocks for the synthesis of bisabolane sesquiterpenes. Their usefulness is shown in the preparation of (S)-(+)-curcuphenol, (S)-(+)-xanthorrhizol, (S)-(-)-curcuquinone and (S)-(+)-curcuhydroquinone. The Royal Society of Chemistry 2000.

Triazine derivatives, a process for preparing the derivatives, and herbicides containing the derivatives as the effective component

A triazine derivative represented by the general formula: STR1 wherein R1 and R2 are each an alkyl group having 1 to 4 carbon atoms, and X1 and X2 are each a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, or an alkylthio group having 1 to 4 carbon atoms. This invention also provides a process for efficiently preparing said triazine derivative and a herbicide containing said triazine derivative as effective component.

ADDITION OF CARBON NUCLEOPHILES TO ARENE-CHROMIUM COMPLEXES

The electrophilic reactivity of arenes coordinated to the chromium tricarbonyl unit has been developed into several distinct methods for coupling carbon nucleophiles with aromatic rings.Addition of the nucleophile produces stable η-cyclohexadienyl chromium complexes which can be oxidized to induce loss of the endo hydrogen and the metal, overall nucleophilic substitution for hydrogen.Alternatively, the intermediate can be protonated and the resulting cyclohexa-1,3-diene can be detached from the chromium, effecting nucleophilic addition with reduction of one double bond.If a halogen (F, Cl) is present as a ring substituent, and if the nucleophile can migrate about the arene ligand, then loss of halide can occur parallel with classical nucleophilic aromatic substitution for halogen in electron-deficient haloarenes.With substituted arenes, the regioselectivity of addition becomes important and is often very high.Particularly useful are strong resonance donor substituents (RO-, R2N-, F-) where selectivity for meta attack is high.Indole provides an excellent example of selective activation, as the six-membered ring complexes selectively and is then susceptible to nucleophilic substitution, predominantly at the 4 and 7 positions.Substitution for halogen is a somewhat limited process and depends upon the nature of the nucleophile.Very reactive nucleophiles add to unsubstituted positions and are often slow to isomerize to the ipso position from which loss of halide can occur.

ipso Nitration. XXIII. Reactions of cyclohexadiene adducts from nitration of 4-ethyltoluene in acetic anhydride

The diastereoisomers of 4-ethyl-1-methyl-4-nitrocyclohexa-2,5-dienyl acetate (1) and 1-ethyl-4-methyl-4-nitrocyclohexa-2,5-dienyl acetate (2) are stereospecifically reduced to the corresponding nitrocyclohexadienols with aluminum hydride.Each dienol is stereospecifically methylated to the corresponding methyl ether with methyl iodide, silver oxide, and potassium hydroxide.Acid-catalysed solvolysis of the acetates 1 and 2 results in the substitution of the acetate moiety by other nucleophiles and these reactions are not stereospecific.The products of rearomatization of dienyl acetates, dienols and dienyl methyl ethers depend on the acidity and ionizing power of the solvents and are readily explained in terms of reactions involving a nitrocyclohexadienyl cation or acetoxy- (hydroxy-, methoxy-)cyclohexadienyl cation as key intermediates.In the 4-acetoxy-4-alkylcyclohexadienyl cation 1,2-migration of the acetoxyl group is more rapid then alkyl migration, but 1,2-alkyl migration is faster then migration of the hydroxyl or methoxyl groups in the corresponding cations. 1-Ethyl-4-methoxy-4-methylcyclohexa-2,5-dien-1-ol and 4-ethyl-3-nitrotoluene are significant minor products in the solvolysis of 1-ethyl-4-methyl-4-nitrocyclohexa-2,5-dien-1-ol in aqueous methanol.Nitration of p-ethyltoluene in the presence of sulfuric acid or in trifluoracetic anhydride gives a mixture of 4-ethyl-2-nitro- and 4-ethyl-3-nitrotoluene in a 2:1 ratio.