3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Base Information

Chemical Name:3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
CAS No.:1336962-50-5
Molecular Formula:C₄₁H₄₅F₃N₄O
Molecular Weight:666.83
Hs Code.:

Synonyms:3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Chemical Property of 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Technology Process of 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

There total 8 articles about 3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1336967-06-6
3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 41049-53-0,773012-60-5
1-phenylcyclopropylamine

: 1336962-50-5
3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃; for 18h;

Reference yield:

: 591-19-5
m-Bromoaniline

: 1336962-50-5
3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / water / 2 h / 35 - 90 °C

2.1: sulfuric acid / 0.75 h / 65 - 80 °C

2.2: 60 °C

3.1: potassium hydroxide / ethanol; water / 0.25 h

3.2: 18 h / Reflux

3.3: pH 4 - 5

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / 100 °C

5.2: 2 h / 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 150 °C / Sealed tube

7.1: potassium hydroxide; water / methanol / 18 h / 100 °C

7.2: pH 5 / Reflux

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / 50 °C

With hydrogenchloride; N-Bromosuccinimide; sulfuric acid; hydroxylamine hydrochloride; water; potassium carbonate; benzotriazol-1-ol; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; 6.1: Suzuki Coupling;

Reference yield:

: 6326-79-0
6-bromoisatin

: 1336962-50-5
3-(1,4'-bipiperidin-1'-ylmethyl)-7-(2-methyl-1-propen-1-yl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 18 h / Reflux

1.3: pH 4 - 5

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / 100 °C

3.2: 2 h / 20 °C

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 150 °C / Sealed tube

5.1: potassium hydroxide; water / methanol / 18 h / 100 °C

5.2: pH 5 / Reflux

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / 50 °C

With N-Bromosuccinimide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;