N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester

Base Information

• Chemical Name: N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester
• CAS No.: 233266-62-1
• Molecular Formula: C₄₂H₃₉F₄N₃O₇S
• Molecular Weight: 805.847

Synonyms:N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester

Chemical Property of N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester

There total 9 articles about N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Nα-9-fluorenylmethoxycarbonyl-cysteine phenacyl ester (233266-53-0) + methyl ethyl N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-allyloxycarbonyl-aminomethyl sulfonium tetrafluoroborate → Nα-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester (233266-62-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4020(99)00323-3

Reference yield:

piperidine (110-89-4) → Nα-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester (233266-62-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 93 percent / dimethylformamide / 72 h / 20 °C

2.1: sodium hydride / dimethylformamide

2.2: 83 percent / dimethylformamide / 2 h / 20 °C

3.1: 71 percent / CH₂Cl₂ / 8 h / 20 °C

4.1: 70 percent / diisopropylethylamine / CH₂Cl₂ / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Metallation / 2.2: Alkylation / 3.1: Alkylation / 4.1: Condensation;

DOI:10.1016/S0040-4020(99)00323-3

Reference yield:

2,3,4,5,6-pentafluoroaniline (771-60-8) → Nα-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester (233266-62-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ethylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C

1.2: 96 percent / tetrahydrofuran / 24 h / 50 °C

2.1: 93 percent / dimethylformamide / 72 h / 20 °C

3.1: sodium hydride / dimethylformamide

3.2: 83 percent / dimethylformamide / 2 h / 20 °C

4.1: 71 percent / CH₂Cl₂ / 8 h / 20 °C

5.1: 70 percent / diisopropylethylamine / CH₂Cl₂ / 20 °C

With ethylmagnesium chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Acylation / 2.1: Substitution / 3.1: Metallation / 3.2: Alkylation / 4.1: Alkylation / 5.1: Condensation;

DOI:10.1016/S0040-4020(99)00323-3

upstream raw materials:

N^α-9-fluorenylmethoxycarbonyl-cysteine phenacyl ester

piperidine

2,3,4,5,6-pentafluoroaniline

N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine

Downstream raw materials:

N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine

Fmoc-Cys(Fnam)-Phe-OMe

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 233266-62-1 N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine phenacyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send