benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

Base Information

Chemical Name:benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride
CAS No.:1264221-69-3
Molecular Formula:C₂₈H₃₃FN₄O₆*ClH
Molecular Weight:577.053
Hs Code.:

benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

Synonyms:benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

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Chemical Property of benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

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Technology Process of benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

There total 17 articles about benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1264221-58-0
benzyl (2S,11S,19aS)-2-[(tert-butoxycarbonyl)amino]-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate

: 1264221-69-3
benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 1264239-42-0
C₁₅H₁₉NO₄*ClH

: 1264221-69-3
benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / dichloromethane / 15 h / 0 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

3.1: thiophenol; caesium carbonate / acetonitrile / 16 h / 20 °C

3.2: 0.08 h

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 0 - 20 °C

5.1: 1-amino-3-(dimethylamino)propane / tetrahydrofuran / 0 - 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; benzene / 20 °C

7.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; ethyl acetate / 1.5 h / 20 °C

8.1: pentafluorophenyl diphenyl-phosphinate / N,N-dimethyl-formamide / 22 h / 20 °C

9.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With pyridine; hydrogenchloride; 1,3-dimethylbarbituric acid; pentafluorophenyl diphenyl-phosphinate; caesium carbonate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-amino-3-(dimethylamino)propane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;

Reference yield:

: 100-39-0
benzyl bromide

: 1264221-69-3
benzyl (2S,11S,19aS)-2-amino-15-fluoro-7,12-dimethyl-5,8,13-trioxo-2,3,6,7,8,9,10,11,12,13,19,19a-dodecahydro-1H,5H-pyrrolo[2,1-c][1,4,7,12]benzoxatriazacyclopentadecine-11-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 16 h

2.1: hydrogenchloride / 1,4-dioxane / 1 h

3.1: pyridine / dichloromethane / 15 h / 0 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

5.1: thiophenol; caesium carbonate / acetonitrile / 16 h / 20 °C

5.2: 0.08 h

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 0 - 20 °C

7.1: 1-amino-3-(dimethylamino)propane / tetrahydrofuran / 0 - 20 °C

8.1: triphenylphosphine; diethylazodicarboxylate / toluene; benzene / 20 °C

9.1: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; ethyl acetate / 1.5 h / 20 °C

10.1: pentafluorophenyl diphenyl-phosphinate / N,N-dimethyl-formamide / 22 h / 20 °C

11.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With pyridine; hydrogenchloride; 1,3-dimethylbarbituric acid; pentafluorophenyl diphenyl-phosphinate; sodium hydrogencarbonate; caesium carbonate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-amino-3-(dimethylamino)propane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;