3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole

Base Information

Chemical Name:3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole
CAS No.:360062-36-8
Molecular Formula:C₂₇H₂₂N₆OS
Molecular Weight:478.577
Hs Code.:

Synonyms:3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole

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Chemical Property of 3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole

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Technology Process of 3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole

There total 6 articles about 3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 147992-79-8
4-(dimethylamino)-2-thioxo-1,2-dihydropyridine-3-carbonitrile

: 360062-35-7
3-amino-2-benzoyl-5-bromomethyl-4-cyano-1-phenylpyrrole

: 360062-36-8
3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole

Guidance literature:: With potassium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1023/A:1017566212124

Reference yield:

: 62321-92-0
α-cyano-β-dimethylaminocrotonamide

: 360062-36-8
3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / POCl₃ / acetonitrile / 2 h / Heating

2: 83 percent / K₂CO₃ / acetone / Heating

3: 89 percent / Br₂ / acetic acid / 0.25 h / 20 °C

4: 63 percent / KOH / dimethylformamide; H₂O / 15 h / 20 °C

With potassium hydroxide; bromine; potassium carbonate; trichlorophosphate; In water; acetic acid; N,N-dimethyl-formamide; acetone; acetonitrile; 3: Torp-Ziegler cyclization;
DOI:10.1023/A:1017566212124

Reference yield:

: 91255-14-0
α-Cyano-β-N-phenylaminocrotonamide

: 360062-36-8
3-amino-2-benzoyl-4-cyano-5-(3-cyano-4-dimethylamino-2-pyridyl)mercaptomethyl-1-phenylpyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / POCl₃ / acetonitrile / 2 h / Heating

2: 83 percent / K₂CO₃ / acetone / Heating

3: 89 percent / Br₂ / acetic acid / 0.25 h / 20 °C

4: 63 percent / KOH / dimethylformamide; H₂O / 15 h / 20 °C

With potassium hydroxide; bromine; potassium carbonate; trichlorophosphate; In water; acetic acid; N,N-dimethyl-formamide; acetone; acetonitrile; 2: Torp-Ziegler cyclization;
DOI:10.1023/A:1017566212124