3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid

Base Information

Chemical Name:3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid
CAS No.:1192322-55-6
Molecular Formula:C₂₇H₂₉NO₆
Molecular Weight:463.53
Hs Code.:

Synonyms:3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid

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Chemical Property of 3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid

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Technology Process of 3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid

There total 9 articles about 3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1192322-53-4
3-(4-[(3-methoxycarbonylphenylcarbamoyl)methoxy]phenyl)adamantane-1-carboxylic acid benzylester

: 1192322-55-6
3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid

Guidance literature:: With 1% Pd/C; hydrogen;
DOI:10.1016/j.bmcl.2009.07.127

Reference yield:

: 1192322-52-3
3-(4-carboxymethoxyphenyl)adamantane-1-carboxylic acid benzylester

: 1192322-55-6
3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; dmap

2: palladium on activated charcoal

With dmap; palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate;
DOI:10.2174/1573406412666151109113007

Reference yield:

: 1192322-49-8
3-(4-ethoxycarbonylmethoxyphenyl)adamantane-1-carboxylic acid benzylester

: 1192322-55-6
3-{4-[(3-methoxycarbonyl-phenyl-carbamoyl)-methoxy]-phenyl}-adamantane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; dmap / N,N-dimethyl-formamide / 20 °C

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

With dmap; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;