Technology Process of (1H-indole-3,7-diyl)bis(phenylmethanone)
There total 5 articles about (1H-indole-3,7-diyl)bis(phenylmethanone) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dirhodium tetraacetate;
In
dichloromethane;
at 20 ℃;
for 4h;
regioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201400161
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1.25 h / 0 - 20 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere
3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere
4: dirhodium tetraacetate / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
dirhodium tetraacetate; 4-toluenesulfonyl azide; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/anie.201400161
- Guidance literature:
-
Multi-step reaction with 5 steps
1: chloroform / 24 h / Reflux; Inert atmosphere
2: 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1.25 h / 0 - 20 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere
4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere
5: dirhodium tetraacetate / dichloromethane / 4 h / 20 °C / Inert atmosphere
With
dirhodium tetraacetate; 4-toluenesulfonyl azide; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane; chloroform; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/anie.201400161