5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide

Base Information

Chemical Name:5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide
CAS No.:402469-35-6
Molecular Formula:C₂₈H₄₃NO₂SSi
Molecular Weight:485.806
Hs Code.:

5-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide

Synonyms:5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide

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Chemical Property of 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide

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Technology Process of 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide

There total 8 articles about 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 402469-34-5
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanoic acid phenethyl-amide

: 402469-35-6
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide

Guidance literature:: With Lawessons reagent; In toluene; at 80 ℃;
DOI:10.1016/S0960-894X(03)00178-1

Reference yield:

: 458-36-6
trans-coniferyl aldehyde

: 402469-35-6
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / NaH / tetrahydrofuran

2: tetrahydrofuran

3: H₂ / Pd/C / methanol

4: 98 percent / PCC / CH₂Cl₂

5: 58 percent / NaH / tetrahydrofuran

6: 81 percent / H₂ / Pd/C

7: 98 percent / Me₃Al / CH₂Cl₂

8: 47 percent / Lawesson's reagent / toluene / 80 °C

With Lawessons reagent; hydrogen; trimethylaluminum; sodium hydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene; 5: Horner-Worthward-Emmons reaction;
DOI:10.1016/S0960-894X(03)00178-1

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 402469-35-6
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-3-ethyl-pentanethioic acid phenethyl-amide

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / NaH / tetrahydrofuran

2: tetrahydrofuran

3: H₂ / Pd/C / methanol

4: 98 percent / PCC / CH₂Cl₂

5: 58 percent / NaH / tetrahydrofuran

6: 81 percent / H₂ / Pd/C

7: 98 percent / Me₃Al / CH₂Cl₂

8: 47 percent / Lawesson's reagent / toluene / 80 °C

With Lawessons reagent; hydrogen; trimethylaluminum; sodium hydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene; 5: Horner-Worthward-Emmons reaction;
DOI:10.1016/S0960-894X(03)00178-1