(4Z)-4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5-one

Base Information

Chemical Name:(4Z)-4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5-one
CAS No.:16352-73-1
Molecular Formula:C₁₇H₁₃NO₂
Molecular Weight:263.296
Hs Code.:
NSC Number:117533
Nikkaji Number:J105.011G
ChEMBL ID:CHEMBL2205188
Mol file:16352-73-1.mol

Synonyms:4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5(4H)-one

Suppliers and Price of (4Z)-4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (4Z)-4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5-one

Chemical Property:

Vapor Pressure:1.57E-06mmHg at 25°C
Boiling Point:397.6°Cat760mmHg
Flash Point:174.7°C
PSA：38.66000
Density:1.15g/cm³
LogP:2.77510
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:263.094628657
Heavy Atom Count:20
Complexity:424

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=NC(=CC3=CC=CC=C3)C(=O)O2
Isomeric SMILES:CC1=CC=C(C=C1)C2=N/C(=C\C3=CC=CC=C3)/C(=O)O2

Technology Process of (4Z)-4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5-one

There total 4 articles about (4Z)-4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: C₁₇H₁₃N₃O₃

: 16352-73-1,72615-38-4
4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5(4H)-one

Guidance literature:: With triphenylphosphine; In toluene; at 20 ℃;
DOI:10.1021/acscatal.6b00165

Reference yield: 78.0%

: 27115-50-0
N-(4-methylbenzoyl)glycine

: 100-52-7
benzaldehyde

: 16352-73-1,72615-38-4
4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5(4H)-one

Guidance literature:: With sodium acetate; acetic anhydride; at 110 ℃; for 1h; Molecular sieve;
DOI:10.1002/jccs.201500111

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 16352-73-1,72615-38-4
4-benzylidene-2-(4-methylphenyl)-1,3-oxazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water

2: sodium acetate; acetic anhydride / 100 °C

With sodium acetate; acetic anhydride; sodium hydroxide; In water;
DOI:10.1016/j.bmcl.2011.05.077