4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid

Base Information

Chemical Name:4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid
CAS No.:77410-31-2
Molecular Formula:C₂₀H₂₃N₉O₅
Molecular Weight:469.46
Hs Code.:

4-amino-4-deoxy-N<sup>10</sup>-methylpteroyl-L-glutamic γ-monohydroxamic acid

Synonyms:4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid

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Chemical Property of 4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid

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Technology Process of 4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid

There total 3 articles about 4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 43170-88-3
diethyl (2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)amino]pentanedioate

: 77410-31-2
4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid

Guidance literature:: With hydroxylamine hydrochloride; sodium; In methanol; for 44h; Ambient temperature;
DOI:10.1021/jm00137a016

Reference yield: 62.0%

: 59-05-2
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

: 77410-31-2
4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid

Guidance literature:: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 0 ℃;

With hydroxylamine; In N,N-dimethyl-formamide; at 0 ℃; Further stages.;
DOI:10.1016/j.bmc.2006.11.017

Reference yield:

: 19741-14-1
4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

: 77410-31-2
4-amino-4-deoxy-N¹⁰-methylpteroyl-L-glutamic γ-monohydroxamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 0.31 g / Et₃N / dimethylformamide / 0.5 h / Ambient temperature

2: 1,1,3,3-tetramethylguanidine / dimethylformamide / 4 h / Ambient temperature

With triethylamine; N,N,N',N'-tetramethylguanidine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00137a016