(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one
CAS No.:1375751-08-8
Molecular Formula:C₂₂H₁₄F₂N₂O₂
Molecular Weight:376.362
Hs Code.:

Synonyms:(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one

Suppliers and Price of (4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one

There total 10 articles about (4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1375754-06-5
(4R,5R)-4-(5-bromopyridin-3-yl)-5-(2,5-difluorophenyl)oxazolidin-2-one

: 536-74-3
phenylacetylene

: 1375751-08-8
(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In acetonitrile; at 80 ℃; for 5h; Inert atmosphere;
DOI:10.1002/adsc.201600329

Reference yield: 85.0%

: 4-(5-bromopyridin-3-yl)-5-(2,5-difluorophenyl)oxazolidin-2-one

: 536-74-3
phenylacetylene

: 1375751-08-8
(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; for 16h; Inert atmosphere; Reflux;

Reference yield:

: 85117-99-3
2-(bromomethyl)-1,4-difluorobenzene

: 1375751-08-8
(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4 h / 160 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 19 h / -10 - 20 °C / Inert atmosphere

3.1: sodium hydroxide; water; tert-butylhypochlorite / propan-1-ol / 0.08 h / Inert atmosphere

3.2: 0 - 22 °C / Inert atmosphere

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 50 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / Inert atmosphere

5.2: 19 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; copper(l) iodide; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / Inert atmosphere; Reflux

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert-butylhypochlorite; potassium tert-butylate; water; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; propan-1-ol; dichloromethane; 1.1: |Michaelis-Arbuzov Synthesis / 2.1: |Horner-Wadsworth-Emmons Olefination / 6.1: |Sonogashira Cross-Coupling;
DOI:10.1021/acsmedchemlett.5b00450