5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol

Base Information

• Chemical Name: 5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol
• CAS No.: 676131-62-7
• Molecular Formula: C₂₂H₂₃BF₃NO₂
• Molecular Weight: 401.236
• Mol file: 676131-62-7.mol

Synonyms:5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol

Chemical Property of 5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol

There total 1 articles about 5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

2-(4-bromo-2-fluorophenyl)-5-(2,6-difluorophenyl)-3,4-dihydro-2H-pyrrol + bis(pinacol)diborane (73183-34-3) → 5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol (676131-62-7)

Guidance literature:

With potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield: 69.9%

5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol (676131-62-7) + 3-(4-bromophenyl)-5-(tert-butyl)-1,2,4-oxadiazole (676131-65-0) → 5-tert-butyl-3-[4'-[5-(2,6-difluorophenyl)-3,4-dihydro-2H-pyrrol-2-yl]-3'-fluoro-1,1'-biphenyl-4-yl]-1,2,4-oxadiazole

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 80 ℃; for 16h;

Reference yield: 60.3%

5-(2,6-difluorophenyl)-2-[2-fluoro-4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3,4-dihydro-2H-pyrrol (676131-62-7) + 5-(4-bromophenyl)-3-tert-butyl-1,2,4-oxadiazole (676131-63-8) → 3-tert-butyl-5-[4'-[5-(2,6-difluorophenyl)-3,4-dihydro-2H-pyrrol-2-yl]-3'-fluoro-1,1'-biphenyl-4-yl]-1,2,4-oxadiazole

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 80 ℃; for 16h;

upstream raw materials:

bis(pinacol)diborane