methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate

Base Information

Chemical Name:methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate
CAS No.:1418287-33-8
Molecular Formula:C₁₇H₁₄ClIN₂O₄
Molecular Weight:472.667
Hs Code.:

Synonyms:methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate

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Chemical Property of methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate

There total 1 articles about methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 153034-90-3
2-Chloro-4-iodo-3-pyridinecarboxaldehyde

: 1418287-33-8
methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate

Guidance literature:: N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.5h;

2-Chloro-4-iodo-3-pyridinecarboxaldehyde; In dichloromethane; at 20 ℃; for 4h; Cooling;

Reference yield:

: 1418287-33-8
methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate

: 1418287-52-1
methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; copper(l) iodide; L-proline / 1,4-dioxane / Inert atmosphere; Reflux

2: palladium diacetate; XPhos; potassium fluoride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 20 °C

With potassium fluoride; copper(l) iodide; palladium diacetate; sodium hydride; potassium carbonate; L-proline; XPhos; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1418287-33-8
methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2-chloro-4-iodopyridin-3-yl)prop-2-enoate

: C₂₆H₂₃F₃N₂O₅

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; copper(l) iodide; L-proline / 1,4-dioxane / Inert atmosphere; Reflux

2: palladium diacetate; XPhos; potassium fluoride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 60 °C

With potassium fluoride; copper(l) iodide; palladium diacetate; sodium hydride; potassium carbonate; L-proline; XPhos; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;