methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

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Chemical Name:methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate
CAS No.:1418287-52-1
Molecular Formula:C₁₉H₁₉BrN₂O₃
Molecular Weight:403.275
Hs Code.:

Synonyms:methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

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Chemical Property of methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

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Technology Process of methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

There total 4 articles about methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1418287-51-0
methyl 4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

: 106-93-4
ethylene dibromide

: 1418287-52-1
methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 688357-19-9
4-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid methyl ester

: 1418287-52-1
methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; XPhos; potassium fluoride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 20 °C

With potassium fluoride; palladium diacetate; sodium hydride; XPhos; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 153034-90-3
2-Chloro-4-iodo-3-pyridinecarboxaldehyde

: 1418287-52-1
methyl 1-(2-bromoethyl)-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

1.2: 4 h / 20 °C / Cooling

2.1: potassium carbonate; copper(l) iodide; L-proline / 1,4-dioxane / Inert atmosphere; Reflux

3.1: palladium diacetate; XPhos; potassium fluoride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 20 °C

With potassium fluoride; copper(l) iodide; palladium diacetate; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; L-proline; XPhos; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;