(S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate

Base Information

• Chemical Name: (S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate
• CAS No.: 158534-32-8
• Molecular Formula: C₂₃H₃₀N₂O₅
• Molecular Weight: 414.502
• Mol file: 158534-32-8.mol

Synonyms:(S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate

Chemical Property of (S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate

There total 1 articles about (S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-benzyloxyamine (622-33-3) + (S)-benzyl-4-oxo-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate (124994-66-7) → (S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate (158534-32-8)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In 1,4-dioxane; methanol; for 48h; Ambient temperature;

DOI:10.1021/jm00049a013

Reference yield: 90.0%

ethoxycarbonylisocyanate (19617-43-7) + (S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate (158534-32-8) → (2S)-benzyl 4--2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate (158534-33-9)

Guidance literature:

In tetrahydrofuran; for 0.0166667h;

DOI:10.1021/jm00049a013

Reference yield:

(S)-benzyl-4-<(O-benzylhydroxy)amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate (158534-32-8) → (2S)-<<(1,1-dimethylethoxy)carbonyl>amino>-4-butanoic acid (1026082-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / tetrahydrofuran / 0.02 h

2: 85 percent / H₂ / 10percent Pd/C / methanol / 3 h / 1551.4 Torr

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00049a013

upstream raw materials:

N-benzyloxyamine

(S)-benzyl-4-oxo-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate

Downstream raw materials:

(2S)-benzyl 4--2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate

(2S)-<<(1,1-dimethylethoxy)carbonyl>amino>-4-butanoic acid