2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate

Base Information

Chemical Name:2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate
CAS No.:1356483-11-8
Molecular Formula:C₂₄H₁₉F₃N₆O₅
Molecular Weight:528.447
Hs Code.:

Synonyms:2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate

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Chemical Property of 2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate

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Technology Process of 2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate

There total 6 articles about 2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 618-94-0
3-nitrobenzoic acid hydrazide

: 1356483-11-8
2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

2.1: phosphorus pentachloride / 1,2-dichloro-ethane / 16 h / Inert atmosphere; Reflux

3.1: hydrazine hydrate / acetonitrile / 1 h / 50 °C

3.2: 24 h / Reflux

3.3: 0 °C

4.1: ammonium formate / 5%-palladium/activated carbon / ethanol / 20 h / Inert atmosphere; Reflux

5.1: tetrahydrofuran / 1 h / 80 °C / Inert atmosphere

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 34 h / 20 °C / Inert atmosphere

With pyridine; phosphorus pentachloride; ammonium formate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1203256-54-5
3-nitro-2-[(trifluoromethyl)benzoyl] hydrazide

: 1356483-11-8
2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / 1,2-dichloro-ethane / 16 h / Inert atmosphere; Reflux

2.1: hydrazine hydrate / acetonitrile / 1 h / 50 °C

2.2: 24 h / Reflux

2.3: 0 °C

3.1: ammonium formate / 5%-palladium/activated carbon / ethanol / 20 h / Inert atmosphere; Reflux

4.1: tetrahydrofuran / 1 h / 80 °C / Inert atmosphere

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 34 h / 20 °C / Inert atmosphere

With phosphorus pentachloride; ammonium formate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1353958-44-7
N'-(chloro(4-(trifluoromethyl)phenyl)methylene)-3-nitrobenzohydrazonoyl chloride

: 1356483-11-8
2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / acetonitrile / 1 h / 50 °C

1.2: 24 h / Reflux

1.3: 0 °C

2.1: ammonium formate / 5%-palladium/activated carbon / ethanol / 20 h / Inert atmosphere; Reflux

3.1: tetrahydrofuran / 1 h / 80 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 34 h / 20 °C / Inert atmosphere

With ammonium formate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;