8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine

Base Information

Chemical Name:8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine
CAS No.:1097698-84-4
Molecular Formula:C₁₉H₁₈N₄O₂
Molecular Weight:334.378
Hs Code.:

Synonyms:8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine

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Chemical Property of 8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine

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Technology Process of 8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine

There total 4 articles about 8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1335230-24-4
N-(3-acetyl-5-cyano-2-methyl-6-methoxy-pyridin-4-yl)-formimidic acid ethyl ester

: 2393-23-9
4-methoxy-benzylamine

: 1097698-84-4
8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine

Guidance literature:: In acetonitrile; at 40 ℃;
DOI:10.1016/j.bmcl.2011.07.067

Reference yield:

: 653587-91-8
5-acetyl-4-amino-6-methyl-2-methylsulfanyl-nicotinonitrile

: 1097698-84-4
8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / acetonitrile / 1.5 h / 50 °C / Reflux

2: methanol / 0.5 h

3: acetic anhydride / 140 °C

4: acetonitrile / 40 °C

With sodium tungstate (VI) dihydrate; dihydrogen peroxide; acetic anhydride; In methanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.07.067

Reference yield:

: 1097700-64-5
5-acetyl-4-amino-6-methyl-2-methoxy-nicotinonitrile

: 1097698-84-4
8-cyano-5-methyl-4-methylene-7-methoxy-3-(4-methoxybenzyl)-3,4-dihydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / 140 °C

2: acetonitrile / 40 °C

With acetic anhydride; In acetonitrile;
DOI:10.1016/j.bmcl.2011.07.067