5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine

Base Information

Chemical Name:5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine
CAS No.:1349723-06-3
Molecular Formula:C₁₅H₁₂BrClFN₃O
Molecular Weight:384.635
Hs Code.:

Synonyms:5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine

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Chemical Property of 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine

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Technology Process of 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine

There total 10 articles about 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1349723-08-5
1-(5-bromo-2-chloropyridin-3-yl)-2-(2-chloro-3-fluoro-6-methoxyphenyl)-propan-1-one

: 1349723-06-3
5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With hydrazine hydrate; In isopropyl alcohol; at 20 - 80 ℃; for 51h;

Reference yield:

: 1263378-40-0
2-chloro-3-fluoro-6-methoxy-benzaldehyde

: 1349723-06-3
5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 3 h / 0 - 20 °C

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 24 °C

3.1: N,N-dimethyl-formamide / 75 °C

4.1: diisobutylaluminium hydride / toluene; hexanes / 2.5 h / 0 - 5 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 0.63 h / -50 °C

5.2: 1 h / -40 °C

6.1: pyridinium chlorochromate / dichloromethane / 41 h / 20 - 40 °C

7.1: hydrazine hydrate / isopropyl alcohol / 51 h / 20 - 80 °C

With isopropylmagnesium chloride; diisobutylaluminium hydride; hydrazine hydrate; methanesulfonyl chloride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; hexanes; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 1175301-75-3
1-(2-chloro-3-fluoro-6-methoxyphenyl)ethanol

: 1349723-06-3
5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 24 °C

2.1: N,N-dimethyl-formamide / 75 °C

3.1: diisobutylaluminium hydride / toluene; hexanes / 2.5 h / 0 - 5 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.63 h / -50 °C

4.2: 1 h / -40 °C

5.1: pyridinium chlorochromate / dichloromethane / 41 h / 20 - 40 °C

6.1: hydrazine hydrate / isopropyl alcohol / 51 h / 20 - 80 °C

With isopropylmagnesium chloride; diisobutylaluminium hydride; hydrazine hydrate; methanesulfonyl chloride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; hexanes; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;