N₁-hydroxy-N₈-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide

Base Information

• Chemical Name: N₁-hydroxy-N₈-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide
• CAS No.: 1350651-18-1
• Molecular Formula: C₂₈H₃₃N₃O₅
• Molecular Weight: 491.587

Synonyms:N₁-hydroxy-N₈-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide

Chemical Property of N₁-hydroxy-N₈-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N₁-hydroxy-N₈-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide

There total 7 articles about N₁-hydroxy-N₈-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

methyl 8-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenylamino)-8-oxooctanoate (1350651-16-9) → N1-hydroxy-N8-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide (1350651-18-1)

Guidance literature:

With hydroxylamine; potassium cyanide; In tetrahydrofuran; methanol; water; at 35 - 40 ℃; for 24h;

Reference yield:

1-amino-naphthalene (134-32-7) → N1-hydroxy-N8-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide (1350651-18-1)

Guidance literature:

Multi-step reaction with 7 steps

1: methanol / 20 °C / Inert atmosphere

2: methanol; sodium tetrahydroborate / 0.17 h

3: 1H-imidazole / dichloromethane / 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5: trifluoroacetic acid / 0.5 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

7: hydroxylamine / potassium cyanide / tetrahydrofuran; methanol; water / 24 h / 35 - 40 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; hydroxylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium cyanide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

N-(2-(tert-butyldimethylsilyloxy)ethyl)naphthalen-1-amine (1350651-81-8) → N1-hydroxy-N8-(4-(2-((2-hydroxyethyl)(naphthalen-1-yl)amino)-2-oxoethyl)phenyl)octanediamide (1350651-18-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: trifluoroacetic acid / 0.5 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

4: hydroxylamine / potassium cyanide / tetrahydrofuran; methanol; water / 24 h / 35 - 40 °C

With hydroxylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium cyanide; In tetrahydrofuran; methanol; dichloromethane; water;

upstream raw materials:

1-amino-naphthalene

N-(2-(tert-butyldimethylsilyloxy)ethyl)naphthalen-1-amine

N-(2-hydroxyethyl)-1-naphthylamine

C₁₂H₁₁NO

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