2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid

Base Information

Chemical Name:2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid
CAS No.:1609188-57-9
Molecular Formula:C₂₁H₂₂O₃
Molecular Weight:322.404
Hs Code.:

Synonyms:2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid

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Chemical Property of 2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid

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Technology Process of 2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid

There total 6 articles about 2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.9%

: 1609188-54-6
2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde

: 1609188-57-9
2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid

Guidance literature:: With sodium chlorite; dihydrogen peroxide; In aq. phosphate buffer; water; acetonitrile; at 0 ℃; pH=4.3;
DOI:10.1016/j.ejmech.2014.04.015

Reference yield:

: 1558039-12-5
(Z)‐9‐chloro‐2,3‐dimethyl‐6,7‐dihydro‐5H‐benzo[7]annulene‐8‐carbaldehyde

: 1609188-57-9
2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; tetrabutylammomium bromide; potassium carbonate / water / 3 h / 45 °C

2: sodium chlorite; dihydrogen peroxide / water; acetonitrile; aq. phosphate buffer / 0 °C / pH 4.3

With sodium chlorite; tetrabutylammomium bromide; dihydrogen peroxide; palladium diacetate; potassium carbonate; In aq. phosphate buffer; water; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.04.015

Reference yield:

: 95-47-6
o-xylene

: 1609188-57-9
2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / dichloromethane / 5 h / Reflux

2: hydrogenchloride; zinc amalgam / toluene / 48 h / Reflux

3: polyphosphoric acid / 2 h / 85 °C

4: trichlorophosphate / 4 h / 0 - 80 °C

5: palladium diacetate; tetrabutylammomium bromide; potassium carbonate / water / 3 h / 45 °C

6: sodium chlorite; dihydrogen peroxide / water; acetonitrile; aq. phosphate buffer / 0 °C / pH 4.3

With hydrogenchloride; aluminum (III) chloride; sodium chlorite; zinc amalgam; tetrabutylammomium bromide; dihydrogen peroxide; palladium diacetate; potassium carbonate; trichlorophosphate; In aq. phosphate buffer; dichloromethane; water; toluene; acetonitrile; 4: |Vilsmeier-Haack Formylation / 5: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.04.015