2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde

Base Information

Chemical Name:2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde
CAS No.:1609188-54-6
Molecular Formula:C₂₁H₂₂O₂
Molecular Weight:306.404
Hs Code.:

Synonyms:2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde

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Chemical Property of 2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde

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Technology Process of 2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde

There total 5 articles about 2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: 1558039-12-5
(Z)‐9‐chloro‐2,3‐dimethyl‐6,7‐dihydro‐5H‐benzo[7]annulene‐8‐carbaldehyde

: 5720-06-9
2-Methoxyphenylboronic acid

: 1609188-54-6
2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde

Guidance literature:: With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; In water; at 45 ℃; for 3h;
DOI:10.1016/j.ejmech.2014.04.015

Reference yield:

: 95-47-6
o-xylene

: 1609188-54-6
2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / dichloromethane / 5 h / Reflux

2: hydrogenchloride; zinc amalgam / toluene / 48 h / Reflux

3: polyphosphoric acid / 2 h / 85 °C

4: trichlorophosphate / 4 h / 0 - 80 °C

5: palladium diacetate; tetrabutylammomium bromide; potassium carbonate / water / 3 h / 45 °C

With hydrogenchloride; aluminum (III) chloride; zinc amalgam; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; trichlorophosphate; In dichloromethane; water; toluene; 4: |Vilsmeier-Haack Formylation / 5: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.04.015

Reference yield:

: 7508-13-6
5-(3,4-dimethyl-phenyl)-5-oxo-valeric acid

: 1609188-54-6
2,3-dimethyl-5-(2-methoxyphenyl)-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; zinc amalgam / toluene / 48 h / Reflux

2: polyphosphoric acid / 2 h / 85 °C

3: trichlorophosphate / 4 h / 0 - 80 °C

4: palladium diacetate; tetrabutylammomium bromide; potassium carbonate / water / 3 h / 45 °C

With hydrogenchloride; zinc amalgam; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; trichlorophosphate; In water; toluene; 3: |Vilsmeier-Haack Formylation / 4: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.04.015