1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole

Base Information

Chemical Name:1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole
CAS No.:180601-40-5
Molecular Formula:C₁₈H₁₈FN₃O₄S
Molecular Weight:391.423
Hs Code.:

Synonyms:1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole

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Chemical Property of 1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole

Chemical Property:

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Technology Process of 1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole

There total 7 articles about 1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 180601-40-5
1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: t-BuOK / dimethylformamide / 4 h / Ambient temperature

2: 30percent aq. H₂O₂ / dimethylformamide / 0 - 20 °C

3: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

4: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; dihydrogen peroxide; nickel; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm970423k

Reference yield:

: 404-90-0
2-(3-fluoro-4-methoxyphenyl)acetonitrile

: 180601-40-5
1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: t-BuOK / dimethylformamide / 4 h / Ambient temperature

2: 30percent aq. H₂O₂ / dimethylformamide / 0 - 20 °C

3: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

4: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; dihydrogen peroxide; nickel; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm970423k

Reference yield:

: 1026593-27-0
(3-Amino-4-nitro-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone

: 180601-40-5
1-Isopropylsulfonyl-2-Amino-6-(3-Fluoro-4-Methoxybenzoyl)benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

2: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

3: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

With pyridine; sodium hydroxide; hydrogen; nickel; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm970423k