ethyl <3--1-hydroxypropyl>methylphosphinate

Base Information

Chemical Name:ethyl <3--1-hydroxypropyl>methylphosphinate
CAS No.:133345-86-5
Molecular Formula:C₁₄H₂₂NO₅P
Molecular Weight:315.306
Hs Code.:

ethyl <3-<N-(benzyloxycarbonyl)amino>-1-hydroxypropyl>methylphosphinate

Synonyms:ethyl <3--1-hydroxypropyl>methylphosphinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl <3--1-hydroxypropyl>methylphosphinate

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Technology Process of ethyl <3--1-hydroxypropyl>methylphosphinate

There total 1 articles about ethyl <3--1-hydroxypropyl>methylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 16391-07-4
ethyl methylphosphinate

: 65564-05-8
3-[(benzyloxycarbonyl)amino]propanal

: 133345-86-5
ethyl <3--1-hydroxypropyl>methylphosphinate

Guidance literature:: With triethylamine; at 100 ℃; for 2h;
DOI:10.1021/jm00017a015

Reference yield:

: 133345-86-5
ethyl <3--1-hydroxypropyl>methylphosphinate

: {3-[(3-benzyloxycarbonylamino-propionyl)-isopropyl-amino]-1-hydroxy-propyl}-methyl-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 5 percent Pd/C / ethanol; H₂O

2: 1.) MgSO₄, 2.) H₂ / 2.) 5 percent Pd/C / 2.) MeOH, acetone 50/50 v.

3: Et₃N / CH₂Cl₂

With hydrogen; magnesium sulfate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1016/S0040-4039(98)02396-X