Cbz-Ala-OCH₂CCH

Base Information

• Chemical Name: Cbz-Ala-OCH₂CCH
• CAS No.: 125376-32-1
• Molecular Formula: C₁₄H₁₅NO₄
• Molecular Weight: 261.277
• Mol file: 125376-32-1.mol

Synonyms:Cbz-Ala-OCH₂CCH

Chemical Property of Cbz-Ala-OCH₂CCH

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Cbz-Ala-OCH₂CCH

There total 2 articles about Cbz-Ala-OCH₂CCH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-Cbz-Ala (1142-20-7) + propargyl bromide (106-96-7) → Cbz-Ala-OCH2CCH (125376-32-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at -10 - 20 ℃;

DOI:10.1071/CH14708

Reference yield: 59.0%

N-Cbz-Ala (1142-20-7) + propargyl alcohol (107-19-7) → Cbz-Ala-OCH2CCH (125376-32-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 0 - 25 ℃; for 3h;

DOI:10.1016/j.jorganchem.2012.03.021

Reference yield: 92.0%

4-(azidomethyl)-7-hydroxy-2H-chromen-2-one (866560-73-8) + Cbz-Ala-OCH2CCH (125376-32-1) → (1-((7-hydroxy-2-oxo-2H-chromen-4-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl((benzyloxy)carbonyl)-L-alaninate

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In ethanol; water; at 20 ℃;

DOI:10.1071/CH14708

upstream raw materials:

N-Cbz-Ala

propargyl alcohol

propargyl bromide