9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A

Base Information

Chemical Name:9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A
CAS No.:955954-05-9
Molecular Formula:C₄₉H₈₅N₃O₁₃
Molecular Weight:924.226
Hs Code.:

Synonyms:9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A

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Chemical Property of 9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A

Chemical Property:

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Technology Process of 9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A

There total 4 articles about 9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 92594-46-2
9-deoxo-9a-aza-9a-demethyl-9a-(3-aminopropyl)-9a-homoerythromycin A

: 501-52-0
3-Phenylpropionic acid

: 955954-05-9
9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm201615t

Reference yield:

: 92594-46-2
9-deoxo-9a-aza-9a-demethyl-9a-(3-aminopropyl)-9a-homoerythromycin A

: 955954-05-9
9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A

Guidance literature:: 3-Phenylpropionic acid; With N-cyclohexanecarbodiimide-N'-propyloxymethyl polystyrene resin; In dichloromethane; at 20 ℃; for 1h; Polystyrene

9-deoxo-9a-aza-9a-demethyl-9a-(3-aminopropyl)-9a-homoerythromycin A; In dichloromethane; at 20 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 76801-85-9
9-Deoxo-9a-aza-9a-homoerythromycin A

: 955954-05-9
9a-(3-[(3-phenylpropanoyl)amino]propyl)-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A

Guidance literature:: Multi-step reaction with 3 steps

1.1: 22 h / 85 °C

2.1: hydrogen / platinum(IV) oxide / acetic acid / 26 h / 3750.38 Torr

3.1: N-cyclohexanecarbodiimide-N'-propyloxymethyl polystyrene resin / dichloromethane / 1 h / 20 °C

3.2: 2 h / 20 °C

With N-cyclohexanecarbodiimide-N'-propyloxymethyl polystyrene resin; hydrogen; platinum(IV) oxide; In dichloromethane; acetic acid;