3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester

Base Information

• Chemical Name: 3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester
• CAS No.: 632626-03-0
• Molecular Formula: C₂₈H₂₇NO₅S
• Molecular Weight: 489.592
• Mol file: 632626-03-0.mol

Synonyms:3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester

Chemical Property of 3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester

There total 7 articles about 3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-{2-[5-methanesulfonyl-2-(hydroxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester (632626-02-9) + benzyl bromide (100-39-0) → 3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester (632626-03-0)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 16h;

Reference yield:

2-hydroxy-5-(methylsulfonyl)benzaldehyde (632628-02-5) → 3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester (632626-03-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / K₂CO₃ / dimethylformamide / 70 °C

2: TEA; 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide / Heating

3: pTSA / toluene / Heating

4: toluene / Heating

5: K₂CO₃ / dimethylformamide / 60 °C

With TEA; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2006.04.073

Reference yield:

2-para-methoxybenzyl-5-methylsulfoxidebenzaldehyde (632626-00-7) → 3-{2-[5-methanesulfonyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester (632626-03-0)

Guidance literature:

Multi-step reaction with 4 steps

1: TEA; 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide / Heating

2: pTSA / toluene / Heating

3: toluene / Heating

4: K₂CO₃ / dimethylformamide / 60 °C

With TEA; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2006.04.073

upstream raw materials:

3-{2-[5-methanesulfonyl-2-(hydroxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester

benzyl bromide

2-hydroxy-5-(methylsulfonyl)benzaldehyde

2-para-methoxybenzyl-5-methylsulfoxidebenzaldehyde