(S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:(S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate
CAS No.:1568827-22-4
Molecular Formula:C₁₆H₂₁BrN₂O₅S
Molecular Weight:433.323
Hs Code.:

Synonyms:(S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate

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Chemical Property of (S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate

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Technology Process of (S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate

There total 4 articles about (S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: methyl (S)-1-((2-aminophenyl)sulfonyl)pyrrolidine-2-carboxylate

: 20769-85-1
2-bromoisobutyric acid bromide

: 1568827-22-4
(S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1002/ejoc.201501558

Reference yield:

: methyl (S)-1-(2-nitrophenylsulfonyl)pyrrolidine-2-carboxylate

: 1568827-22-4
(S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / 12 h / 3102.97 Torr

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With palladium on activated charcoal; hydrogen; triethylamine; In dichloromethane;
DOI:10.1039/c3cc48850k

Reference yield:

: (S)-pyrrolidine-2-carboxylic acid methyl ester hydrochloride

: 1568827-22-4
(S)-methyl 1-(2-(2-bromo-2-methylpropanamido)-phenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol

3: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1039/c3ra47039c