20769-85-1

Basic information

• Product Name: 2-Bromoisobutyryl Bromide
• Synonyms: alpha-BroMoisobutyryl broMide 98%;2-Bromoisobutyryl bromide for synthesis;BROMOISOBUTYRYL(2-) BROMIDE;2-BROMOISOBUTYRYL BROMIDE;2-BROMO-2-METHYLPROPIONYL BROMIDE;A-BROMOISOBUTYRYL BROMIDE;ALPHA-BROMOISOBUTYRYL BROMIDE;2-Bromo-2-methylpropanoyl bromide
• CAS NO: 20769-85-1
• Molecular Formula: C₄H₆Br₂O
• Molecular Weight: 229.9
• EINECS: 244-017-3
• Product Categories: Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 20769-85-1.mol

Chemical Properties

• Boiling Point: 162-164 °C(lit.)
• Flash Point: >110°C
• Appearance: Clear light yellow to yellow/Liquid
• Density: 1.86 g/mL at 20 °C
• Refractive Index: n20/D 1.507(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: Miscible with acetone and carbon disulfide.
• Water Solubility: reacts
• Sensitive: Moisture Sensitive
• Stability: Stable, but may react with moisture. Incompatible with water, strong oxidizing agents, strong bases.
• BRN: 1746128
• CAS DataBase Reference: 2-Bromoisobutyryl Bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromoisobutyryl Bromide(20769-85-1)
• EPA Substance Registry System: 2-Bromoisobutyryl Bromide(20769-85-1)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 20769-85-1(Hazardous Substances Data)

Usage

Sources

http://www.chemicalland21.com/specialtychem/finechem/2-BROMOISOBUTYRYL%20BROMIDE.htm https://www.alfa.com/zh-cn/catalog/B24249/ https://www.sigmaaldrich.com/catalog/product/aldrich/252271?lang=en®ion=US https://pubs.acs.org/doi/abs/10.1021/bk-2003-0854.ch025

Chemical Properties

colourless liquid

Uses

Different sources of media describe the Uses of 20769-85-1 differently. You can refer to the following data:
1. 2-Bromoisobutyryl bromide is used to prepare N-protected halodienamide, which provides four- and five-membered lactams in the presence of copper(I) and a tertiary amine. Further, it is used as atom transfer radical polymerization(ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide. It is also used in preparation of polycaprolactone macroinitiators through reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface.
2. α-Bromoisobutyryl bromide has been used:as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxideto form an N-protected halodienamide which provided four- and five-membered lactams in the presence of copper (I) and a tertiary aminein preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface

Upstream product

• 2736-37-0 isobutyryl bromide 
• 79-31-2 isobutyric Acid 
• 7726-95-6 bromine 
• 79-30-1 isobutyryl chloride 

Downstream Products

• 13887-51-9 2-bromo-2-methyl-1-morpholinopropan-1-one 
• 50630-62-1 5,5-dimethyl-2,3,4,5-tetrahydro-2,4-furandione 
• 101287-61-0 2,5,5-trimethyl-4-oxo-1-phenyl-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester 
• 127049-21-2 2-bromo-1-(2-hydroxy-5-methyl-phenyl)-2-methyl-propan-1-one 
• 117346-37-9 p-tolyl 2-bromo-2-methylpropanoate 
• 5455-11-8 1-[(1,1'-Biphenyl)-4-yl]-2-bromo-2-methylpropan-1-on 
• 294642-61-8 N-benzyl-2-bromo-2-methyl-N-phenylpropanamide 
• 116729-22-7 α-bromo-isobutyric acid-(2-nitro-phenyl ester) 
• 598-26-5 dimethylketene 
• 7462-74-0 2-bromo-2-methylpropanamide 
• 2322-49-8 p-methyl-α-bromoisobutyranilide 
• 69737-57-1 α-bromo-isobutyric acid o-tolyl ester 
• 294642-59-4 α-bromo-isobutyric acid-(N-ethyl-anilide) 
• 2322-52-3 2-bromo-2-methyl-N-(4-nitrophenyl)propanamide 

Relevant articles and documents

Use of 2-phenylmorpholin-5-one derivatives

A 2-phenylmorpholin-5-one derivative having the formula (I): wherein R1 represents a C1 to C8 alkyl group, a C3 to C7 cycloalkyl group or an indanyl group, R2 represents a C1 to C4 alkyl group, R3 represents a hydrogen atom, a C1 to C5 alkyl group, etc., R4 represents a hydrogen atom, a C1 to C6 alkyl group, etc., R5, R6 represent a hydrogen atom, a C1 to C5 alkyl group, etc.,an optical isomer thereof or a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof and a pharmaceutical composition containing the same.The above compound has a strong type IV phosphodiesterase (PDE) inhibitory activity and has bronchodilater and antiinflammatory effects.